Search on: DNA POLYMERASE II 
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Descriptor English:   DNA Polymerase II 
Descriptor Spanish:   ADN Polimerasa II 
Descriptor Portuguese:   DNA Polimerase II 
Synonyms English:   DNA-Dependent DNA Polymerase II
Pol II
DNA Polymerase epsilon  
Tree Number:   D08.811.913.696.445.308.300.230
Definition English:   A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents. EC 2.7.7.7. 
History Note English:   84(77); for DNA POLYMERASE EPSILON use DNA POLYMERASE II (NM) 1994-97 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   4324 
Unique Identifier:   D004257 

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